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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 20
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Research Articles

A new dimeric alkylresorcinol from the stem barks of Swintonia floribunda (Anacardiaceae)

Phu H. DangFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam; ORCID Iconhttp://orcid.org/0000-0002-4989-9315
ORCID Icon,
Linh T. T. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;
,
Hue T. T. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;
,
Tho H. LeFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;
,
Truong N. V. DoFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;
,
Hai X. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;
,
Nghia D. LeFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam;
,
Mai T. T. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam; ;Cancer Research Laboratory, Vietnam National University, Ho Chi Minh City, Vietnam
&
Nhan T. NguyenFaculty of Chemistry, VNUHCM–University of Science, Ho Chi Minh City, Vietnam; ;Cancer Research Laboratory, Vietnam National University, Ho Chi Minh City, Vietnam
 show all
Pages 2883-2889 | Received 15 May 2018, Accepted 04 Aug 2018, Published online: 07 Oct 2018
 
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Abstract

From an EtOAc-soluble fraction of the stem barks of Swintonia floribunda (Anacardiaceae), one new dimeric alkylresorcinol named integracin E (1), together with 4 known compounds (2–5) were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The absolute configuration of 1 was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product. Compound 1 showed potent tyrosinase inhibitory activity with an IC50 value of 48.2 μM.

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Disclosure statement

No potential conflict of interest was reported by the authors.

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