Antioxidant coumarin and pyrone derivatives from the insect-associated fungus Aspergillus Versicolor

Abstract

Two new compounds, versicolones A and B (1 and 2), and three known pyrone derivatives (3−5) were isolated from the insect-associated fungus Aspergillus versicolor. Their structures were elucidated through a combination of HRESIMS and NMR spectroscopic analysis. Versicolone A (1) was revealed as a coumarin derivative with the rare 5-alkyl side chain substitution. Compound 5 exhibited significant antioxidant activity with EC₅₀ value of 8.0 μM in the ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) assay, which was more than 2-fold potency of the positive control trolox.

Graphical Abstract

Keywords:

• Insect-associated fungus
• Aspergillus versicolor
• coumarin
• antioxidant activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China [U1604176], the Science and Technology Planning Project of Henan Province [182102310651], and the Ph.D. Programs Foundation of Zhengzhou University of Light Industry [13501050056].