New onoceranoid xyloside from Lansium parasiticum

Abstract

A novel onoceranoid triterpene xyloside named methyl lansioside C (1) together with two known glycosides (2 and 3) were isolated from polar fraction of the fruit peels of Lansium parasiticum. The structure and absolute configuration of the new compound were established using extensive spectroscopic techniques as well as Mosher’s method. The antioxidant activity and α-glucosidase inhibitory effect of the isolated compounds were evaluated. Compounds 1 and 3 displayed moderate radical scavenging activity with SC₅₀ values of 14.5 and 13.7 mM, respectively. However, all isolated compounds exhibited no inhibition against α-glucosidase.

Graphical Abstract

Keywords:

• Onoceranoid
• triterpene
• glycoside
• Lansium parasiticum
• Lansium domesticum
• Meliaceae
• antioxidant

Acknowledgement

RR is grateful to the Graduate School of Chulalongkorn University for a Postdoctoral Fellowship (Ratchadaphisek Sompot Fund). This project was supported by the Thailand Research Fund via the Directed Basic Research Grant (DBG 5980001). The Center of Excellence in Natural Products was subsidized by Chulalongkorn University.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This project was supported by the Thailand Research Fund via the Directed Basic Research Grant (DBG 5980001). The Center of Excellence in Natural Products was subsidized by Chulalongkorn University