Crystal structure and configuration revision of 9-hydroxy-7,8-dehydro-sarcotrocheliol and sarcotrocheliol

Abstract

Herein, we report the isolation and stereo-structure of rare pyrane-based cembranoid diterpenes, 9-hydroxy-7,8-dehydro-sarcotrocheliol (1) and sarcotrocheliol (2), from Sarcophyton trocheliophorum collected from Red Sea. Absolute configurations of both compounds were revised based on single crystal X-ray analyses.

Graphical Abstract

Keywords:

• Sarcophyton trocheliophorum
• pyrane-based cembranoids
• absolute configuration
• X-ray analyses
• crystal structure

3. Experimental (see supplementary data)

Acknowledgements

The authors are thankful to the NMR and MS Departments in Bielefeld University for the spectral measurements. We thank Marco Wißbrock and Anke Nieß for technical assistance.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research work has been financed by the German Academic Exchange Service (DAAD) with funds from the German Federal Foreign Office in the frame of the Research Training Network “Novel Cytotoxic Drugs from Extremophilic Actinomycetes” (ProjectID 57166072).