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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 21
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Research Articles

Centaurea microcarpa Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents

Samia BaatoucheUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie;
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Thamere CherietUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie; ;Département de chimie, Faculté des sciences, Université Mohammed Boudiaf-M’sila, M’sila, Algérie;
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Djamel SarriDépartement de Biologie, Faculté des sciences, Université Mohammed Boudiaf-M’Sila, M’Sila, Algérie; ORCID Iconhttp://orcid.org/0000-0003-3617-1162
ORCID Icon,
Ratiba MekkiouUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie;
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Ouahiba BoumazaUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie;
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Samir BenayacheUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie;
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Fadila BenayacheUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie;
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Ignacio BrouardInstituto de Productos Naturales y Agrobiología-CSIC, Instituto Universitario de Bio-Orgánica ‘Antonio González’, Universidad de La Laguna, La Laguna, Tenerife, Spain
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Francisco LeónInstituto de Productos Naturales y Agrobiología-CSIC, Instituto Universitario de Bio-Orgánica ‘Antonio González’, Universidad de La Laguna, La Laguna, Tenerife, Spain
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Ramdane SeghiriUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie; Correspondence[email protected]
 show all
Pages 3070-3076 | Received 30 Apr 2018, Accepted 26 Aug 2018, Published online: 16 Nov 2018
 
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Abstract

The phytochemical investigation of both chloroform and ethyl acetate extracts of Centaurea microcarpa Coss. & Dur. led to the isolation of a new cyanogenic glucoside 6'-methacrylate prunasin (3) together with seven known compounds: hydroxy-11β,13-dihydro onopordaldehyde (1), β-sitosterol (2), daucosterol (4), nepetin (5), prunasin (6), astragalin (7) and 7-O-β-D-glucopyranosyl centaureidin (8). Their structures were established by spectral analysis, mainly UV, IR, ESI-MS, 1D & 2D-NMR experiments (COSY, HSQC, HMBC and ROESY).

Graphical Abstract

Disclosure statement

No potential conflict of interests was reported by the authors.

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