A new polyhydroxylated oleanane triterpenoid from the roots of Rhodomyrtus tomentosa

Abstract

A new oleanane triterpenoid, 2α,3β,6β,23,29-pentahydroxyolean-12-en-28- oic acid (1), was isolated from the roots of Rhodomyrtus tomentosa, together with four known oleanane triterpenoids (2–5) and two known ursane triterpenoids (6–7). The structure of compound 1 was determined by extensive NMR and HR-ESI-MS data analysis. Compounds 4–5 showed cytotoxicity against PC12 cell lines at a concentration of 50 μM, and compound 1 exhibited moderate neuroprotective activity against corticosterone induced PC12 cell death at the same concentration.

Keywords:

• Rhodomyrtus tomentosa
• Oleanane triterpenoid
• Neuroprotective activity

Acknowledgments

The authors thank Analytical & Measuring Centre, South China Sea Institute of Oceanology of Sciences, C.A.S. for optical rotation and IR measurements.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [grant number 81703381], The Ph.D Start-up Fund of Natural Science Fundation of Guangdong Province, China [grant number 2017A030310531], and Guangdong Medical Science Foundation [grant number A2018203].