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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 3
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Research Articles

Antimicrobial lavandulylated flavonoids from a sponge-derived actinomycete

, , , , , , , , & show all
Pages 413-420 | Received 04 Sep 2018, Accepted 16 Oct 2018, Published online: 23 Dec 2018
 

Abstract

Analysis of an antimicrobial culture broth extract of the sponge-derived actinomycete Streptomyces sp. (strain G246) led to the isolation of two new lavandulylated flavonoids, 6-lavandulyl-7-methoxy-5,2′,4′-trihydroxylflavanone (1) and 5′-lavandulyl-4′-methoxy-2,4,2′,6′-tetrahydroxylchalcone (2), along with eight known compounds 310. Their structures were established by spectral data analysis, including MS, 1D, 2D-NMR and CD. The absolute configurations of 1 and 2 were suggested by comparison of their experimental and calculated electronic circular dichroism spectra. All the isolated compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 1 and 2 had a broad-spectrum of antimicrobial activity. Additionally, except the strain Escherichia coli, compound 2 exhibited remarkable inhibitory activity against Pseudomonas aeruginosa, Salmonella enterica, Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, and Candida albicans strains.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The Vietnam Academy of Science and Technology (VAST) are gratefully acknowledged for financial support (Grant No: VAST.TĐ.DLB.04/16-18).

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