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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 8
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Research Articles

Acrepyrone A, a new γ-pyrone derivative from an endophytic fungus, Acremonium citrinum SS-g13

Xiao-Ping PengDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; View further author information
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Gang LiDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; ORCID Iconhttp://orcid.org/0000-0003-0621-2779View further author information
ORCID Icon,
Li-Xia JiDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; View further author information
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Ying-Xia LiDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; View further author information
&
Hong-Xiang LouDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; ;Department of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 1091-1096 | Received 25 Oct 2018, Accepted 09 Nov 2018, Published online: 19 Jan 2019
 
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Abstract

A new γ-pyrone derivative, acrepyrone A (1), and three known sorbicillinoids, trichodimerol (2), dihydrotrichodimerol (3) and tetrahydrotrichodimerol (4) were isolated from an endophytic fungus, Acremonium citrinum SS-g13, harboured in the roots of the Chinese medicinal plant Fructus mori. Their structures were determined by analysing MS, NMR, and ECD data. Compound 1 was evaluated for its cytotoxic effect, antibacterial activity and quorum sensing inhibitory potential.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported financially by the National Natural Science Foundation of China (grant number 40218030034) and the Natural Science Foundation of Shandong Province (grant number ZR2018BC001).

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