New sesquiterpenoid glycoside from the rhizomes of Atractylodes lancea

Abstract

Six sesquiterpenoids and four lignans (1–10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2–4) were first obtained from this genus. All the isolates were elucidated by spectroscopic analyses and chemical methods, and the absolute configurations were assigned by electronic circular dichroism spectroscopy technique. In addition, the cytotoxic bioassay of compound 1 was evaluated and results showed it had no significant antitumor activity against human cancer cell lines MCF-7, HepG-2 and Hela.

Graphical Abstract

Keywords:

• Atractylodes lancea
• rhizomes
• sesquiterpenoids
• lignans
• absolute configuration

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was supported by the National Natural Science Foundation of China [grant numbers 81573601], Youth Teacher Development Support scheme of Shenyang Pharmaceutical University (2014) and the Project of Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education of Shenyang Pharmaceutical University.