A new oleanane type pentacyclic triterpenoid saponin from the husks of xanthoceras sorbifolium bunge and its neuroprotection on PC12 cells injury induced by Aβ_25-35

Abstract

A new triterpenoid saponin (1), 3-O-[β-D-glucopyranosyl(1→6)]-(2′-angeloyl)-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl(1→6)[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-21-O-acetyl-16-deoxybarringtogenol C, together with four known saponins (2 ∼ 5) were isolated from the husks of Xanthoceras sorbifolium Bunge. Their structures were characterized by HR-ESI-MS, 1D-NMR, 2D-NMR spectra and chemical methods. Compound 1 exhibited excellent neuroprotection on PC12 cells injury induced by Aβ_25-35 at the doses of 150 μmol/L and 200 μmol/L. The cell viabilities were (76.18 ± 2.09) % and (76.02 ± 3.20) %, respectively.

Keywords:

• Xanthoceras sorbifolium Bunge
• triterpenoid saponins
• neuroprotection
• Alzheimer′s disease

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Key Technologies of Common Quality Evaluation of New Drugs under Grant [number 2015010201]; National Major Scientific Foundation of China under Grant [number U1508220]; and Liaoning Distinguished Professor Project for Qing Li under Grant [number 2017].