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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 4
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Research Articles

Noroleanane-type triterpenoids from Dolichos trilobus L. and their anti-α-glucosidase activities

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Pages 600-606 | Received 05 Oct 2018, Accepted 02 Mar 2019, Published online: 31 Mar 2019
 

Abstract

Falcatane A (1) and B (2), 4-oxo-3,24-dinor-2,4-secooleanane- and 3-oxo-24- noroleanane-type triterpenoids, together with seven known triterpenoids involving 2-hydroxy-3-oxo-24-noroleana-1,4,12-trien-28-oic acid (3) and oleanolic acid (4), were separated from the ethyl acetate roots extract of Dolichos trilobus using the column chromatography of silica gel, MCI gel, and Sephadex LH-20. The compounds were determined by analysis of IR, NMR spectroscopic data and mass spectrometry. In the bioassay, all isolates showed varying degree of the α-glucosidase inhibitory activity except compound 2.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (NSFC No. 81460535, 21262047), the Yunnan Provincial Applied Basic Research Projects (No. 2017FD122), the Yunnan Provincial Department of Education Science Research Fund Projects (No. 2017YJS058).

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