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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 20
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Research Articles

Two new compounds from the marine sponge derived fungus Penicillium chrysogenum

Xiao HanSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, China; ;Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, China; View further author information
,
Pinglin LiSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, China; ;Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, China; View further author information
,
Xiangchao LuoSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, China; ;Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, China; View further author information
,
Dan QiaoSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, China; ;Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, China; View further author information
,
Xuli TangCollege of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Guoqiang LiSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, China; ;Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, China; Correspondence[email protected] [email protected]
View further author information
Pages 2926-2930 | Received 28 Jan 2019, Accepted 18 Mar 2019, Published online: 08 Apr 2019
 
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Abstract

Two new compounds (1 and 2) were isolated from the marine sponge derived fungus Penicillium chrysogenum by using various column chromatography techniques. Their structures were elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 exhibited moderate activity against PTP1B with 2.95 ± 0.97% at the concentration of 30 μmol·L−1.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 41876161, 41776136), NSFC-Shandong Joint Fund for Marine Science Research Centers (Grant No. U1606403).

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