Abstract
A new plumbagin derivative, 3-(5-oxohexyl)plumbagin (1), together with six known benzoquinone derivatives (2–7), four known triterpenoids (8–11) and coniferyl aldehyde (12) were isolated from Diospyros undulata roots. Their structures were elucidated by intensive spectroscopy including 1 D and 2 D NMR, UV, IR and MS spectrometric analysis. Compound 1 exhibited strong cytotoxicity against three cancer cell lines as lung cancer (NCI-H187), breast cancer (MCF-7), and oral cancer (KB) with IC50 values of 7.16, 12.85 and 28.67 µM, respectively. Moreover, it did not showed cytotoxicity to Vero cells. In addition, the antimicrobial activity of compound 1 was moderate that kill only S. aureus with MBC of 250 µg/mL while other compounds especially compound 4 showed a broader activity that kill all tested bacteria.
Graphical Abstract
Acknowledgements
We thank the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Natural Products Research Unit, Department of Chemistry, Khon Kaen University for partial support. We acknowledge Rajamangala University of Technology Isan for kindly providing the research facilities. We are indebted to the National Center for Genetic Engineering and Biotechnology (BIOTEC) for the bioactivity tests.
Disclosure statement
No potential conflict of interest was reported by the authors.