Cytotoxic p-terphenyls from the deep-sea-derived Aspergillus candidus

Abstract

From the deep-sea-derived fungus Aspergillus candidus, one novel (1) and three known (2–4) p-terphenyl derivates were isolated. The structure of the new compound was established mainly on the basis of extensive analysis of 1D and 2D NMR data. All four isolates were tested for in vitro anti-food allergic and antitumor bioactivities. Compounds 3 and 4 showed potent antiproliferative effect against four cancer cells of Hela, Eca-109, Bel-7402, and PANC-1 with IC₅₀ values ranging from 5.5 μM to 9.4 μM.

GRAPHICAL ABSTRACT

Keywords:

• Fungus
• the Atlantic Ocean
• in vitro
• antitumor
• anti-allergy

Acknowledgements

The authors wish to thank Prof. Guangming Liu of the Jimei University for the anti-allergic tests.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Scientific Research Foundation of Third Institute of Oceanography (2018009), Xiamen Southern Oceanographic Center Project (17GYY026NF05, 17GYY002NF02), COMRA program (DY135-B2-08), and the National Natural Science Foundation of China (21877022).