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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 12
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Identification Of Potential Cytotoxic Inhibitors From Physalis Minima

Viet Cuong Le Canha Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang street, Hue city Vietnam;
,
Vinh Le Bae Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet street, Hanoi city, Vietnam;g College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea
,
Pham Thi Hai Yena Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang street, Hue city Vietnam;;b Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet street, Hanoi city, Vietnam
,
Lien Le Thia Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang street, Hue city Vietnam;;b Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet street, Hanoi city, Vietnam
,
Pham Thi Thuy Hoaia Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang street, Hue city Vietnam;
,
Ton That Huu Data Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang street, Hue city Vietnam;
,
Do Thi Thaoc Institute of Biotechnology, VAST, 18 Hoang Quoc Viet street, Hanoi city, Vietnam
,
Long Giang Bachd Nguyen Tat Thanh University, 300A Nguyen Tat Thanh street, Ho Chi Minh city, Vietnam
,
Young Ho Kimg College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of KoreaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-7441-9459
ORCID Icon &
Hoang Le Tuan Anha Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang street, Hue city Vietnam;;b Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet street, Hanoi city, VietnamCorrespondence[email protected] [email protected]
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Pages 2082-2085 | Received 19 Jun 2019, Accepted 28 Jul 2019, Published online: 12 Aug 2019
 
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Abstract

A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4β-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines. As the obtained results, compounds 1 and 3 displayed the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cell lines with IC50 value ranging from 0.051 ± 0.004 to 0.86 ± 0.09 μg/mL.

Graphical Abstract

Acknowledgements

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2016.26.

Disclosure statement

No potential conflict of interest was reported by the authors.

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