Iridoid compounds from the aerial parts of Swertia mussotii Franch. with cytotoxic activity

Abstract

One new secoiridoid compound swertiamarin B (1), along with a known compound lytanthosalin (2), were isolated from ethanol extract of the aerial parts of Swertia mussotii. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were first isolated from the Swertia genus. Their antitumor activities were evaluated for four human tumor cell lines (HCT-116, HepG2, MGC-803 and A549). Compounds 1 and 2 showed excellent cytotoxic activities toward the MGC-803 cell lines with IC₅₀ values 3.61 and 12.04 μM, respectively.

Keywords:

• Gentianaceae
• NMR spectroscopy
• Swertia mussotii
• secoiridoid
• antitumor activity assay

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 11872232 and 11432008).