Two new norsesquiterpenoids with estrogenic activity from the stems and leaves of Dioscorea oppositifolia L

Abstract

Two new norsesquiterpenoids, dioscopposin A (1) and dioscopposin B (2), as well as 21 known compounds (3–23) were isolated from the stems and leaves of Dioscorea oppositifolia L. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. The absolute configurations were deduced by the comparison of experimental and calculated electronic circular dichroism spectra. Estrogenic activity of all the isolated compounds were evaluated using MCF-7 cells proliferation assay and compounds 2, 3, 7, 13, 15, 16, 18 and 21 exhibited proliferation activity.

Graphical Abstract

Keywords:

• Dioscorea oppositifolia L.
• Dioscoreaceae
• norsesquiterpenoids
• estrogenic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the Central Government Guide Local Science and Technology Development Funds ([2016]149) and the Study on the Key Technology for Quality Control and the Key Characteristics (171100310500).