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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 19
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Diarylpentanones from the root of Wikstroemia indica and their cytotoxic activity against human lung A549 cells

Zhihui Liua School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
,
Mengyu Donga School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
,
Xiangyang Qiua School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
,
Na Hana School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
&
Jun Yina School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China;b Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected] [email protected]
Pages 3346-3349 | Received 08 Oct 2019, Accepted 18 Nov 2019, Published online: 09 Dec 2019
 
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Abstract

One new diarylpentanone, 4(S)-hydroxy-1, 5-diphenyl -2(E)-en-1-pentanone (1), two diarylpentanones isolated from Wikstroemia indica for the first time (3 and 5) and two other known diarylpentanones were isolated from petroleum ether fraction of root of Wikstroemia indica. The structure of the new compound including absolute configuration was elucidated by extensive spectroscopic techniques, including 1D, 2D NMR, HR-ESI-MS and ECD spectroscopy. All isolated compounds were tested for their cytotoxic activity against cancer-derived cell lines A549. Compound 5 exhibited remarkable cytotoxic activity comparable to that of positive control cisplatin.

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