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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 20
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Research Articles

Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Nguyen Thi Maia University of Transport and Communications, Ha Noi, VietnamView further author information
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Vu Van Doanb Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
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Hoang Thi Tuyet Lana University of Transport and Communications, Ha Noi, VietnamView further author information
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Bui Thi Mai Anha University of Transport and Communications, Ha Noi, VietnamView further author information
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Nguyen Huy Hoangb Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
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Bui Huu Taib Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;c Graduate University of Science and Technology, VAST, Hanoi, VietnamView further author information
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Nguyen Xuan Nhiemb Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;c Graduate University of Science and Technology, VAST, Hanoi, VietnamView further author information
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Pham Hai Yenb Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
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Seon Ju Parkd College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, KoreaORCID Iconhttps://orcid.org/0000-0002-0532-5977View further author information
ORCID Icon,
Yohan Seod College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, KoreaView further author information
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Wan Namkungd College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, KoreaView further author information
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Seung Hyun Kimd College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, KoreaORCID Iconhttps://orcid.org/0000-0003-2613-0674View further author information
ORCID Icon &
Phan Van Kiemb Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;c Graduate University of Science and Technology, VAST, Hanoi, VietnamCorrespondence[email protected]
View further author information
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Pages 3360-3369 | Received 06 Sep 2019, Accepted 21 Nov 2019, Published online: 12 Dec 2019
 
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Abstract

Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by Vietnam Ministry of Education and Training under grant number HH01, 2019.

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