https://orcid.org/0000-0001-8227-0618
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Abstract
Two new lathyrane diterpenoids, euphanoids A and B (1 and 2), along with five known compounds (3–7) were isolated from the roots of Euphorbia kansuensis. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by single crystal X-ray diffraction. All of the isolates were screened for the inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells, and compounds 1 and 2 showed pronounced inhibition on NO production with IC50 values of 4.7 and 9.5 μM, respectively, being more active than the positive control, quercetin (IC50 = 10.8 μM).
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by National Natural Science Foundation of China (Nos. 81722042, 81973195 and 81973203).