Two new compounds from the stewed Polygonatum cyrtonema Hua and their protective effect against Aβ_25-35 induced cytotoxicity and oxidative stress damage

Abstract

A new alkaloid polygonatine C (3-(2’-furaldehyde-5’-methoxymethyl)5,6,7,8 -tetrahydroindolizin-8-one, 1) and a new saponin huangjingsterol B (3-β-hydroxyspirost-5,25-diene-12-one, 2), together with three known compounds 3–5 were isolated from the ethanolic extract of the Stewed Polygonatum cyrtonema Hua. The structures of these new compounds were identified by extensive spectroscopic analysis including 1D and 2D NMR and MS, as well as chemical methods. The new compounds were tested for their Protective effect against Aβ_25-35 induced cytotoxicity and oxidative stress damage in PC12 cells. The results indicated that compounds 1–2 can be considered as promising lead compounds for further research on Alzheimer’s disease (AD) treatment.

Graphical Abstract

Keywords:

• Polygonatum cyrtonema Hua
• alkaloid
• saponin
• cytotoxicity
• oxidative stress

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Academic and Technical Leader Program of Jiangxi Province (20182BCB22005), The Natural Science Foundation of Jiangxi Province (20171BAB205083), Jingxi Provincial Key Research and Development General Project (20181BBC70046, 20192BBG70071), Jiangxi Provincial Health and Family Planning Commission for Chinese Medicine Research Project (2016A023), Jiangxi Provincial Traditional Chinese Medicine First-class Discipline Special Research Fund (JXSYLXK-ZHYAO119, JXSYLXK-ZHYAO137), and Funds from China Scholarship Council (201808360274).