Muriolide, a novel antioxidant lactone from Ranunculus muricatus

Abstract

Muriolide (1), a new aromatic lactone, has been isolated from the ethyl acetate fraction of Ranunculus muricatus. The compound was structurally characterized with the help of UV, IR, mass, 1D- and 2D-NMR data. It was tested in vitro for antioxidant and lipoxygenase inhibitory potential. Compound 1 showed good DPPH radical scavenging activity (IC₅₀=56.9 μM), however it was moderately active against lipoxygenase enzyme (IC₅₀=68.3 μM).

Graphical Abstract

Keywords:

• Ranunculus muricatus
• muriolide
• free radical scavenging activity
• lipoxygenase inhibition
• antioxidant

Acknowledgements

The authors gratefully acknowledge the H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan for providing laboratory facilities related to isolation and characterisation of natural products.

Disclosure statement

No potential conflict of interest was reported by the authors.