The combination of N-Acetyl-L-Cysteine, Pelargonium sidoides and Justicia adhatoda (NAXX) exerts bacteriostatic activity against S. aureus and E. coli

Abstract

Many herbal agents and medicinal plants have provided clinical interest due to their therapeutic properties, availability and lower side effects. The aim of this study was to understand the anti-bacterial activity of the combination of Pelargonium sidoides (PEL), Justicia adhatoda (ADH) and N-Acetyl-L-Cysteine (NAC) (NAXX). We found that NAXX had strong and long-term bacteriostatic activity, which was related to its anti-oxidant activity. Our data demonstrate that NAXX is an innovative medicinal plant-derived strategy to manage of oxidative stress- and microbial-based diseases.

Graphical Abstract

Keywords:

• N-Acetyl-L-Cysteine
• Pelargonium sidoides
• Justicia adhatoda
• anti-oxidant
• anti-microbial activity

Disclosure statement

UDM from Shedir Pharma SpA provided the extract object of the study. The other authors do not disclose any conflict of interest.

Author contribution

MT and CC performed the experiments; UDM provided the compounds; AP and RS supervised the experimental protocol; MT wrote the manuscript; RS approved the final version of the manuscript.