A new hexenoic acid glycoside with cytotoxic activity from the leaves of Psychotria luzoniensis

Abstract

A new hexenoic acid glycoside (1) together with known compounds, flavonol glycosides (2–4), iridoid glycoside (5), megastigmane glycoside (6), and amino acid (7) were isolated from the leaves of P. luzoniensis by resin column chromatography and preparative HPLC. Their structures were determined based on spectroscopic analysis, including HRFABMS and NMR (¹H and ¹³C, ¹H−¹H COSY, HMQC, and HMBC) data. All compounds tested for cytotoxicity were active (IC₅₀ < 50 μM) with IC₅₀ values ranging from 1.97 to 32.85 μM against human colon adenocarcinoma cell line, compared to etoposide (IC₅₀ 1.19 μM).

Graphical Abstract

Keywords:

• Psychotria luzoniensis
• hexenoic acid glycoside
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Acknowledgment

The authors gratefully acknowledge the fund and support given to RJD Ramil and MDI Ramil by the Mariano Marcos State University and Tohoku Medical and Pharmaceutical University.