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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 1
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Research Articles

Secondary metabolites isolated from Agrimonia pilosa Ledeb.

Hong-Rui LiKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaView further author information
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Yu-Kui LiKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaView further author information
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Jian XiaoKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaView further author information
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Cui YangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaView further author information
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Meng-Yuan JiangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaView further author information
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Kai TianKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaView further author information
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Wei WangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaView further author information
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Yan-Hong LiKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaCorrespondence[email protected] [email protected]
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Xiang-Zhong HuangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnomedicine and Ethnopharmacy, Yunnan Minzu University, Kunming, P.R. ChinaCorrespondence[email protected] [email protected]
View further author information
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Pages 263-270 | Received 11 Dec 2019, Accepted 24 May 2020, Published online: 22 Jun 2020
 
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Abstract

A pilot study on the ethanol extracts of Agrimonia pilosa found to have anti-α-glucosidase and anti-inflammatory activities. Subsequent chemical study afforded a new phenylethyl isocoumarin glycoside (1) and eight known compounds (2-9). The structure of 1 was elucidated by comprehensive spectroscopic analysis and chemical transformations. All compounds showed modest α-glucosidase inhibitory activity (IC50 values ranging from 36.8 to 210.7 μM), which was lower than that of the positive control acarbose (IC50=301.9 μM). Those compounds except inactive compounds 3 and 6 showed weak anti-inflammatory activity.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Financial support was provided by the National Natural Science Foundation of China (NSFC No. 81960783), the Yunnan Provincial Applied Basic Research Projects (No. 2017FD122), National Students’ platform for innovation and entrepreneurship training program (No. 201910691008).

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