Traphanoside GO1, a new triterpenoid saponin from the aerial parts of Glinus oppositifolius with the inhibitory effect on PGE2 production in LPS-induced HepG2 cells

Abstract

A new saponin, 3-O-[α-ʟ-rhamnosyl-(1→3)-β-D-glucopyranosyl]-28-O-β-D-glucopyranosyl serjanic acid (Traphanoside GO1, 11) along with eleven compounds (1-10 and 12) were isolated from the aerial parts of Glinus oppositifolius. The structures of all isolates were elucidated by analyzing extensive 1 D- and 2 D-NMR and HR-ESI-MS, comparing with reported literature data. Compounds 7-8, 10-11, and 90% ethanol extract (GOE90) were evaluated for the inhibitory effect on PGE2 production from activated HepG2 cells. Among these, new compound 11 showed the most potent inhibitory activity by suppressing LPS-induced PGE2 production on the HepG2 cells.

Graphical Abstract

Keywords:

• Glinus oppositifolius
• Traphanoside GO1
• 3-O-[α-ʟ-rhamnosyl-(1→3)-β-D-glucopyranosyl]-28-O-β-D-glucopyranosyl serjanic acid
• PGE2
• HepG2 cell

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Traphaco Join Stock Company under Grant 809-TRA issued 1/6/2016) for “Studying of chemical compositions in Glinus oppositifolius (L.) A. DC., Molluginaceae”. We are grateful to the Korean Basic Science Institute for spectroscopic measurements.