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Abstract
Acacia etbaica is wild plant growing in the desert of Egypt, and it has folkloric medicinal uses. Phytochemical investigation of Acacia etbaica extracts led to the isolation and identification of seven compounds. Among these compounds are three new simple phenolics: Resacetophenone-6-methyl [1], Resorcinol [2], Resorcinol-O- β -Glucoside [3]; phenolic ester; and other four known compounds: Methylparaben [4]; two chromones, Noreugenin [5], Eugenin [6]; and one cyclitol: pinitol [7]. Compounds [1–3] isolated and identified for the first time from natural origin. In contrast, compounds [4–6] isolated for the first time from the family Fabaceae. The biological investigation was conducted on plant extracts and showed that the methylene chloride extract had a strong efficacy against Bacillus subtilis and good activity against Candida albicans. In contrast, the n-butanol extract showed extreme cytotoxic activity against Mammary gland breast cancer (MCF-7), and strong activity against Hepatocellular carcinoma (HEPG-2), and Colorectal carcinoma (HCT-116) cell lines.
Graphical Abstract
Acknowledgments
We would like to express my deepest gratitude to Nuclear Magnetic resonance Unit, Faculty of Pharmacy, Mansoura University for sample analysis, NMR support, and cooperation.
Authors’ contributions
Hazem A. Kadry and Ezzat A. M. Genady, researched literature and conceived the study. EL- Sayed. M. El-ghaly and Akram M. Kayed, was involved in protocol development, experimental studies, and data analysis. EL- Sayed. M. El-ghaly, Ezzat A. M. Genady, Hazem A. Kadry and Akram M. Kayed, wrote the first draft of the manuscript. All authors reviewed and edited the manuscript and approved the final version of the manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).