A new depsidone derivative from mangrove endophytic fungus Aspergillus sp. GXNU-A9

Abstract

A new tetracyclic depsidone derivative, guanxidone A (1), together with three known metabolites 2–4, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. The structure of compound 1 was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data. Compounds 1–4 were evaluated for their anti-inflammatory effects on the production of the nitric oxide (NO), and compound 1 significantly reduced the production of NO in lipopolysaccharide (LPS)-stimulated cells with IC₅₀ value of 8.22 µM.

Graphical Abstract

Keywords:

• Aspergillus sp.
• mangrove endophytic fungus
• guanxidone A
• anti-inflammatory effects

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors (J. Li. and X.S. Huang) acknowledge the following agencies for funding this project: National Natural Science Foundation of China (21662004); the Natural Science Foundation of Guangxi Province (2018JJD140035, 2018JJA140613, and 2017JJB120059); the Open Research Fund Program of the Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (CMEMR2019-A1); Guangxi Science and Technology Base Special Talents (2019AC20095).