New iridoid glucosides from the roots of Rothmannia wittii (Craib) Bremek

Abstract

Phytochemical investigation of the roots of Rothmannia wittii led to the isolation of three new iridoid glucosides, named rothmanniosides A–C (1–3), and nine known compounds (4–12). Their structures, including their absolute configurations, were elucidated by thorough analysis of mass spectrometric and NMR spectroscopic data, together with CD calculations. Compounds 4 and 11 are reported from the Rubiaceae family for the first time.

Graphical Abstract

Keywords:

• Rothmannia wittii
• Rubiaceae
• iridoid glucosides

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the centre of Excellence for Innovation in Chemistry (PERCH-CIC) and Khon Kaen University. A.W. thanks the Science Achievement Scholarship of Thailand (SAST) for a scholarship.