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Abstract
Eurya acuminata DC and Croton caudatus Gieseler are two ethno-medicinal plants used by Kuki community of North East India. From these plants, we have characterized fifteen phytochemicals (1–15) by extensive use of chromatographic and spectroscopic methods. They were also tested for in vitro cytotoxic effects against A549 and MIAPACA2 cell lines and antimicrobial activities against Mycobacterium smegmatis and Candida albicans. All compounds showed moderate activity against the MIAPACA2 cell lines. Compounds tricosan-1-ol (6), octacosanoic acid (7), β-sitosterol (10) and (E)-dodec-3-en-1-ol (14) exhibited promising activity against A549 cell lines with IC50 of 16.72, 4.5, 4.42 and 4.5 μg/ml respectively. Further, hexatriacontan-1-ol (2) exhibited lowest MIC of 50 μg/ml against C. Albicans and henicosan-1-ol (3) at 25 μg/ml against M. smegmatis. They were also screened through docking analysis against two Phosphatidylinositol-3-Kinase nodal proteins and three feedback loop proteins of cancers. Thus, this study validates their traditional uses as herbal anticancer and antimicrobial agents.
Graphical Abstract
Acknowledgement
The authors are thankful to the Director, CSIR-NEIST for provision of facilities. We also thank CSIR, New Delhi (CSC0207 & 0130, OLP2020), DBT (BT/PR25189/NER/95/1067/2017) and MoTA, India (NFST-2015-17-ST-ASS-3740, 201718-NFST-ASS-00448) for funding.
Disclosure statement
No potential conflict of interest was reported by the authors.
Correction Statement
This article has been republished with minor changes. These changes do not impact the academic content of the article.