Two new chemical constituents from the rhizomes of Actaea dahurica

Abstract

A new phenylpropanoid allopyranoside (1) and a new indolinone alkaloid (2) were isolated from the rhizomes of Actaea dahurica (syn. Cimicifuga dahurica). The structures of those two compounds were deduced as cimicifugaside F (1) and 3E,11E-(3-methyl-2-butenylidene acid)-2-indolinone-1-O-β-d-glucopyranoside (2) by detailed analysis of their MS, 1D and 2D NMR data and comparison with literatures. Additionally, the isolates were evaluated for their inhibitory effects on the production of NO by LPS-stimulated RAW 264.7 macrophages.

Graphical Abstract

Keywords:

• Actaea dahurica
• phenylpropanoid allopyranoside
• indolinone alkaloid
• NO

Disclosure statement

No potential conflict of interest was reported by the authors.

Acknowledgement

The authors are grateful to State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co. Ltd. for their assistance of activity test.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China for financial support to this research (Nos. 81602984, 81630097 and 81803347) and National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Thirteen Five-year Plan Period (2018ZX09711001-008-005).