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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Research Articles

Biological effect of astaxanthin on alcohol-induced gut damage in Carassius auratus used as experimental model

, , , , , ORCID Icon & show all
Pages 5737-5743 | Received 09 Jul 2020, Accepted 12 Sep 2020, Published online: 09 Oct 2020
 

Abstract

Alcohol and its metabolites are responsible for damage both within the gastrointestinal tract and other organs. Alcohol abuse promote intestinal inflammation, that may be the cause of multiple organ dysfunctions and chronic disorders. In this research, the effect of astaxanthin, a powerful antioxidant with several biological effects, on alcohol damage-induced in the intestine of Carassius auratus, was investigated. In the fishes exposed to ethanol, an increase of the intestinal epithelium mucous cells and circulating macrophages, with intestinal mucosa disorganization was observed. In contrast, in the fishes treated with astaxanthin intestinal morphology was restored. By immunohistochemical analysis, using α-Smooth Muscle Actin (α-SMA) and Vasoactive intestinal polypeptide (VIP) antibodies, a reduction of inflammatory states alcohol-induced was evident, with more regular muscularis submucosa and more organized intestinal mucosa without inflammatory cells. The results suggest that astaxanthin treatments can be a good candidate for preventing damage within the gastrointestinal associated with excessive alcohol consumption.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

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