Isolation and identification of two new compounds from the seeds of Moringa oleifera and their antiviral and anti-inflammatory activities

Abstract

Eleven compounds were isolated from methanol extract taken from Moringa oleifera seeds, including two previously unknown and nine known compounds. These compounds were authenticated as a carbamate, three phenylglycosides, four phenol glycosides, two nucleosides, and one flavonoid. Their chemical structures were elucidated using 1 D/2D nuclear magnetic resonance and high resolution-MS. Antivirus activity analyses revealed that Moringa A, glucomoringin, and Vitexin possessed strong inhibitory effects against the H1N1 virus, having IC₅₀ values in the range of IC₅₀ = 0.26 ± 0.03, 0.98 ± 0.17, and 3.42 ± 0.37 μg/mL, respectively. Furthermore, these three compounds could decrease the levels of TNF-α, IL-6, and IL-1β, which occur in hosts because of H1N1 infections.

Graphical Abstract

Keywords:

• Anti-inflammatory
• anti-influenza virus
• Moringa oleifera seeds
• phenol glycosides

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (NO. 81973293, 31670360), Program of Guangdong Provincial Science and Technology Plan (2019B1515120029) and the Guizhou Provincial Research Foundation for Basic Research, China (Grant No. Qiankehejichu [2018]1426).