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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 4
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Secondary metabolites from Lantana camara L. flowers extract exhibit in vivo anti-urolithiatic activity in adult Wistar albino rats

Marwa I. Ezzata Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-7776-0265
ORCID Icon,
Salsabeel N. El Gendya Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence[email protected]
,
Ahmed S. Saadb Department of Pharmacology and Toxicology, Faculty of Pharmacy, Port Said University, Port Said, Egypt
,
Walied S. Abdoc Department of Pathology, Faculty of Veterinary Medicine, Kaferelsheik University, Kafrelsheikh, Egypt
,
Aly M. EL Sayeda Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
&
Amira K. Elmotayama Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Pages 1115-1117 | Received 05 Aug 2020, Accepted 16 Nov 2020, Published online: 21 Dec 2020
 
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Abstract

The present study aims at evaluating potential of the ethanol extracts of L. camara leaves (LE), flowers (FlE) and roots (RE) in the treatment of renal calculi and characterising the secondary metabolites in the active extract. The results revealed that the FlE had significantly reduced the levels of kidney parameters (calcium, creatinine, urea, and uric acid) against ethylene glycol (EG) injuries, and restored the activity of glutathione peroxidase (GPx), superoxide dismutase and lipid peroxide malondialdehyde to the normal level. In addition, FlE significantly attenuated iNOS tissue expression caused by EG. The results obtained in this study suggest the potential value of the L. camara L. flowers as an antiurolithiatic agent.

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Disclosure statement

The authors declare no conflict of interest.

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