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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 5
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Short Communication

New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity

Yan Xionga State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China;d Guizhou Nursing Vocational College, Guiyang, ChinaView further author information
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Ping Yia State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
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Yuhuan Lic Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
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Rongmei Gaoc Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
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Junlei Chena State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
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Zhanxing Hua State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
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Huayong Loua State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
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Caixia Dua State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
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Jiayu Zhanga State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
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Yu Zhange State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of Botany, Chinese Academy of Sciences, Kunming, ChinaView further author information
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Chunmao Yuana State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
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Liejun Huanga State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaView further author information
,
Xiaojiang Haoa State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, China;e State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of Botany, Chinese Academy of Sciences, Kunming, ChinaView further author information
&
Wei Gua State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou medical university, Guiyang, China;b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and, Chinese Academy of Sciences, Guiyang, ChinaCorrespondence[email protected]
View further author information
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Pages 1151-1160 | Received 28 Sep 2020, Accepted 05 Dec 2020, Published online: 17 Dec 2020
 
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Abstract

Phytochemical studies led to the isolation of five new sesquiterpeniod esters, named balsamiferine N-R, along with ten known compounds (6-15) from the leaves of Blumea balsamifera (L.) DC. The skeletons of nine known sesquiterpeniods belong to guaiane and eudesmane. The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic analysis, and quantum-chemical electronic circular dichroism (ECD) calculation. Compounds 3 and 4 showed significant inhibitory effects on influenza A virus (H3N2) with IC50 values of 46.23 μg/mL and 38.49 μg/mL, respectively. It was the first report on the anti-influenza A virus constituents from B. balsamifera.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from the Science and technology project of Guizhou Province (QKHZC[2018]2799), the National Natural Science Foundation of China (31860074, U1812403), and Financial support from Guizhou Province Engineering Research Center for Natural Drugs.

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