Abstract
To search for antifungal leads, the metabolites of an insect-derived fungus Fusarium lateritium ZMT01 were investigated, providing five sesquiterpenes (1–5), including new molecules microsphaeropsisins D and E (1 and 2). The evaluated antifungal activities in vitro which are higher than the positive control triadimefon include: 1 and 2 towards Fusarium oxysporum (MICs 50, 25 mg L−1; triadimefon 100 mg L−1); 1, 2, 4 and 5 towards Penicillium italicum (MICs 25, 12.5, 25, 25; triadimefon 50 mg L−1), 1, 2 and 4 towards Colletotrichum musae (MICs 25, 12.5, 25; triadimefon 80 mg L−1), 2 and 4 towards Fusarium graminearum (MICs 100, 100; triadimefon 150 mg L−1). The bioassay in vivo displayed that the banana anthracnose control effect of 2 (100 mg L−1) was also higher than that of triadimefon (Inhibition ratios 27.5 ± 2.5%, 55.3 ± 1.4%, 52.1 ± 1.3% for 2, 22.5 ± 2.1%, 47.2 ± 2.0%, 36.6 ± 2.2% for triadimefon at 4 d, 8 d and 12 d, respectively).
Disclosure statement
The authors declare no conflict of interest.
Supplementary material
Supplementary material relating to this article is available online, alongside Experiments S1 and S2, Tables S1–S3 and Figures S1–S25.
Correction Statement
This article has been republished with minor changes. These changes do not impact the academic content of the article.