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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 5
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Research Article

Bioactive isocoumarins isolated from a mangrove-derived fungus Penicillium sp. MGP11

Rong-Qing Meia Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaView further author information
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Bin Wanga Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaView further author information
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Wei-Nv Zenga Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaView further author information
,
Guo-Lei Huanga Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaView further author information
,
Guang-Ying Chena Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaView further author information
&
Cai-Juan Zhenga Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, ChinaCorrespondence[email protected]
View further author information
Pages 1260-1265 | Received 29 Sep 2020, Accepted 06 Jan 2021, Published online: 18 Jan 2021
 
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Abstract

Two new isocoumarins penicimarins L-M (1–2), along with seven known analogues (3–9) were isolated from the mangrove-derived fungus Penicillium sp. MGP11. Compounds 1–2 were established by spectroscopic methods and comparison of their circular dichroism (CD) spectra with the literature. All isolated compounds were evaluated for antioxidant and α-glucosidase inhibitory activities. Compound 8 had better antioxidant activity (IC50 = 4.6 μM) than positive control trolox (IC50 = 12.9 μM). Compounds 5, 8 and 9 exhibited α-glucosidase inhibitory activity with the IC50 values of 776.5, 683.7 and 868.7 μM, respectively.

Disclosure statement

The authors report no conflicts of interests.

Additional information

Funding

This work was supported by the Key Research and Development Program of Hainan Province (No. ZDYF2018183), National Natural Science Foundation of Hainan Province (No. 218MS045), and the National Natural Science Foundation of China (No. 31760093).

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