Two new monoterpenoid indole alkaloids from Mappianthus iodoides stems

Abstract

Two previously unreported monoterpenoid indole alkaloids, 19(20)E-5-carboxymethylvallesiachotamine (1) and 19(20)Z-5-carboxymethylvallesiachotamine (2), along with five known indole alkaloids (3–7) were isolated from Mappianthus iodoides stems. Their structures were characterized by extensive spectroscopic data. Among these isolates, compounds 1 and 2 were the two new Δ¹⁹⁽²⁰⁾ geometric isomers. The anti-inflammatory activities in vitro of all isolated compounds were evaluated using NO assay.

Keywords:

• Mappianthus iodoides
• monoterpenoid indole alkaloids
• anti-inflammatory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National Key Project of Science and Technology of China “Important New Drugs Innovation” (2017ZX09301045), Chinese Academy of Sciences (CAS) 135 Program (XTBG-F02) and CAS “Light of West China Program” (Y9XB061K01).