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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 20
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Research Article

Phyllaciduloids E and F, two new cleistanthane diterpenoids from the leaves of Phyllanthus acidus

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Pages 5241-5246 | Received 08 Nov 2020, Accepted 09 May 2021, Published online: 02 Jun 2021
 

Abstract

Phyllaciduloids E (1) and F (2), two new cleistanthane diterpenoids, were isolated from the leaves of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their planar structures were established by spectroscopic analysis and comparison with literature values. The relative configurations of phyllaciduloids E and F were confirmed by DFT-NMR chemical shift calculations and subsequent CP3 probability methods. Phyllaciduloids E and F were evaluated for their cytotoxicity. However, no significant activities were detected at concentrations up to 40 μM.

Acknowledgments

We are grateful to the staffs of the analytical and bioactivity screening group at the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for measuring the spectroscopic data and cytotoxic activity.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Key Project of Basic Research Plan of Yunnan Province, China (202001AS070017) and the National Natural Science Foundation of China (82074124).

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