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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 16
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Research Articles

Chemical constituents from Lycopodiella cernua and their anti-inflammatory and cytotoxic activities

Vu Huong Gianga Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Le Thi Thuyb School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, VietnamView further author information
,
Pham Thi Chama Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
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Le Ba Vinha Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;c College of Pharmacy, Wonkwang University, Iksan, Republic of KoreaCorrespondence[email protected]
View further author information
,
Ninh Khac Bana Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Tran My Linha Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Nguyen Chi Maia Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Pham Thi Hoea Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Tran Thu Huongb School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, VietnamView further author information
,
Nguyen Hai Dangd University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Hyuncheol Ohc College of Pharmacy, Wonkwang University, Iksan, Republic of KoreaView further author information
&
Tran Hong Quanga Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamCorrespondence[email protected]
View further author information
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Pages 4045-4051 | Received 26 Mar 2021, Accepted 12 Jul 2021, Published online: 09 Sep 2021
 
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Abstract

Phytochemical investigation of the whole plants of Lycopodiella cernua resulted in the isolation and identification of three new compounds (1–3), namely lycocernuaside E (1), lycernuic ketone F (2), and lycernuic B (3) and 12 known ones (4–15). Their chemical structures were established based on 1 D/2D NMR spectroscopic and HR-ESI-MS data analyses. Compounds 5, 12, and 13 displayed NO inhibitory effects in LPS-stimulated BV2 cells, with IC50 values of 21.2 ± 1.1, 28.5 ± 1.4, and 21.9 ± 1.1 µM, respectively. In addition, cytotoxic activity of the isolated compounds against MCF7 (breast carcinoma), HepG2 (hepatocarcinoma), and SK-Mel2 (melanoma) cancer cell lines were also reported.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2018.07.

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