Polyisoprenylated benzophenones and xanthones from the pericarp of Garcinia planchonii Pierre

Abstract

Two new polyisoprenylated benzophenones, planchoniones A (1) and B (2), together with two known benzophenones (3, 4) and six known xanthones (5-10), were isolated from an ethyl acetate extract of the pericarp of Garcinia planchonii Pierre. Their structures were established using spectroscopic methods, mainly 1D and 2D NMR. The four benzophenones were evaluated for their cytotoxicity against MCF-7 human breast cancer cells, and showed almost no activity. Meanwhile, compounds 5-10 were investigated for their inhibitory effects towards α-glucosidase, and γ-mangostin (5) exhibited the most remarkable effect with IC₅₀ value of 15.3 ± 0.9 µM (compared with acarbose, IC₅₀ = 224.9 ± 3.6 µM).

Graphical Abstract

Keywords:

• Garcinia planchonii
• Clusiaceae
• polyisoprenylated benzophenones
• xanthones
• cytotoxicity
• α-glucosidase inhibitory activity

Disclosure statement

The authors declare no conflict interest.

Additional information

Funding

This research work was funded by Vietnam National University Ho Chi Minh City (VNU-HCM) under the Grant number C2019-18-14.