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Natural Product Research
Formerly Natural Product Letters
Volume 37, 2023 - Issue 7
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Research Articles

Two pairs of epimers and three undescribed diterpenoids from Pseudocaryopteris paniculata

Cheng-Gang Zhanga The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;b Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, P. R. China;c Guiyang University of Chinese Medicine, Guiyang, P. R. ChinaView further author information
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Ting Chena The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;b Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, P. R. ChinaView further author information
,
Jun-Jie Yanga The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;b Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, P. R. ChinaView further author information
,
Xu-Dong Maoa The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;b Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, P. R. ChinaView further author information
&
Gui-Xin Choua The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;b Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, P. R. ChinaCorrespondence[email protected]
View further author information
Pages 1074-1081 | Received 15 Apr 2021, Accepted 19 Sep 2021, Published online: 07 Oct 2021
 
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Abstract

A phytochemical investigation on the petroleum ether partition of the whole plant of Pseudocaryopteris paniculata, yield seven new compounds: one phytanes diterpenoid (2Z,6E,10E) 14-keto-2,6,10-trimethyl pentadeca-2,6,10-trien-1-carboxylic acid (1), five clerodane diterpenoids: paniculatins A-E (2, 3a/3b, 4a/4b), one abietane diterpenoid: ent-uncinatone (5), together with 12 known compounds. Their structures were elucidated on the basis of 1D and 2D Nuclear Magnetic Resonance （NMR_, Infrared Radiation (IR), and mass spectroscopic data. Compound 2, 5, and 11 showed weak selective cytotoxic activity of 11 human cancer cell lines.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support from the National Nature Science Foundation of China (No. 21672152) is gratefully acknowledged.

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