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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 21
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Research Articles

Taberdines L and M, two new alkaloids from Tabernaemontana divaricata

Lingling Hana School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, P.R. China;b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
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Kepu Huanga School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, P.R. China;b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
,
Chen Chenb State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
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Wentao Zhub State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
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Yehan Mab State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
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Xiaojiang Haob State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
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Hongping Hea School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, P.R. ChinaView further author information
&
Yu Zhangb State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaCorrespondence[email protected]
View further author information
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Pages 5470-5475 | Received 07 Oct 2021, Accepted 26 Nov 2021, Published online: 22 Dec 2021
 
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Abstract

Two new alkaloids, taberdines L (1) and M (2), together with six known alkaloids, were isolated from the twigs and leaves of Tabernaemontana divaricata. Taberdine L (1) represents the first optically active natural member of the allo iboga class of alkaloids with the ethyl side chain in a bridgehead position. Their structures including absolute configuration were elucidated by a combination of MS, NMR, and ECD calculation. The in vitro cytotoxic activities of 1 and 2 against five human cancer cell lines were also evaluated.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was financially supported by the National Natural Science Foundation of China (81874295) and Top Young Talent of the Ten Thousand Talents Program of Yunnan (to Y. Zhang).

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