Myobontioids A-D and antifungal metabolites from the leaves of Myoporum bontioides A. Gray

Abstract

A new sesquiterpene glucoside (1), two new norsesquiterpenes (2, 3), and a new homomonoterpene (4), named myobontioids A-D respectively, along with twelve known flavonoids and lignans (5–16) were isolated from Myoporum bontioides A. Gray. Flavanones 5-11 specifically inhibited Phytophthora capsici and Magnaoeporthe grisea at the concentrations of 125, 250 and 500 µg.mL⁻¹. Notably, the new compound 4 possessed a strong activity against Phytophthora capsici with IC₅₀ below 63.5 µg.mL⁻¹ and 90.4% inhibition at 125 µg.mL⁻¹.

Graphical Abstract

Keywords:

• Myoporum bontioides
• sesquiterpene glucoside
• norsesquiterpene
• homomonoterpene
• myobontioids A-D
• antifungal activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2018.36.