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Abstract
Investigation into the chemical diversity of Solanum lyratum led to the discovery of one new sesquiterpenoid, solyraterpenoid A (1), and two known compounds (2 and 3). The structure incorporating absolute configuration of 1 was determined via spectroscopic data, mainly including HRESIMS and NMR, and single-crystal X-ray diffraction analysis. Compound 1 showed significant antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae with MIC values of 8, 8, and 4 μg/mL, respectively.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This work was financially supported by the Program for Foundation of Health and Family Planning Commission of Hubei Province (WJ2017F079) and Soft Science Project of Taihe Hospital (2018JJXM111 and 2019SCI011).