A new antiprotozoal compound from Calendula officinalis

Abstract

A new phytoconstituent; (6Z,9Z)-heptadeca-6,9-diene-5,11-dione (1) was isolated from Calendula officinalis methanol extract. The structure of 1 was determined based on the analysis of NMR spectra and HRESIMS. It was tested for antimicrobial and antiprotozoal activities. Compound 1 showed leishmanicidal activity against L. donovani amastigote with an IC₅₀ of 16.4394 µM and IC₉₀ of 28.9015 µM and a weak antitrypanosomal activity with an IC₅₀ of 37.6136 µM. The cytotoxicity of 1 was evaluated using standard experimental procedures against THP1 cells and no cytotoxicity was observed indicating its selectivity and safety.

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Graphical Abstract

Keywords:

• Malaria
• leishmanicidal
• antimicrobial
• antitrypanosomal

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.