Two new terpenoids with anti-inflammatory activity from the fruits of Arenga pinnata (Wurmb) Merr.

Abstract

Two new terpenoids (1 and 2), arenterpenoid D (1) and pinnasesquiterpene A (2), along with 16 phenylpropanoids (3–18) and 8 known terpenoids (19–26) were isolated from 70% EtOH extract of the Arenga pinnata (Wurmb) Merr. fruits. Their structures were elucidated by spectroscopic methods including HR-ESI-MS, 1D, and 2D NMR. The absolute configuration of arenterpenoid D (1) was defined by X-ray crystallographic analysis. Furthermore, we evaluated the anti-inflammatory activity of all compounds, and outcomes showed that 2 and 21 exposed moderate suppressive effects against NO generation in lipopolysaccharide-stimulated RAW 264.7 cells.

Graphical Abstract

Keywords:

• Terpenoids
• phenylpropanoids
• RAW 264.7; Arenga pinnata

Acknowledgements

The authors thank Ms. Pan Juan and Mr. Guan Wei of the Heilongjiang University of Chinese Medicine for the measurements of NMR and MS spectra, respectively.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was suported by Heilongjiang Touyan Innovation Team Program; Innovative Research Project for graduate students of Heilongjiang University of Chinese Medicine (2020yjscx009); Sustainable use for valuable Chinese medicine resources (2060302); and China Agriculture Research System (CARS-21).