Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH

Abstract

Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4–6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (1–6) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of 70.27%. In addition, the cytotoxic effect of compounds (1–6) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity.

Graphical Abstract

Keywords:

• Ganoderma lucidum
• nor-triterpenoid
• FAAH
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Foundation Project: National Natural Science Foundation of China (No. 81960703, 81560632), the Natural Science Foundation of Liaoning Province (No.2021‐MS‐283), the Dalian Young Star of Science and Technology (2021RQ013), Natural Science Foundation of Jiangxi Province (No. 20202BABL216073), the Natural Science Foundation for Academic and Technical leaders of Jiangxi Province (20212BCJ23026), the Project of Jiangxi Provincial Health and Family Planning Commission (No. 202130182), Traditional Chinese Medicine Science and Technology Plan of Jiangxi Provincial Health and Family Planning Commission (No. 2020A0346).