New coumarin from the roots of Prangos pabularia growing wild in Tajikistan

Abstract

Dichloromethane and butanol extracts of the roots of Prangos pabularia were analyzed to determine chemical constituents and biological activity. The new coumarin 1, yuganin B ((5-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-((2-oxo-2H-chromen-7-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-3,4-dihydroxytetrahydrofuran-3-yl)methyl 4-hydroxy-3-methoxybenzoate) along with three phenolic and twenty-four known coumarins were isolated from the roots of Prangos pabularia, and the structures of these isolated compounds were elucidated by UV, HR-ESIMS, and 1 D and 2 D NMR spectroscopy. In addition, the anti-melanogenic effect of several of the isolated individual compounds and their inhibitory effect on B16 cells were evaluated. Isolating and testing compounds may proof to be useful in the treatment of hyperpigmentation and as a skin-whitening agent in the cosmetics industry.

Graphical Abstract

Keywords:

• B16 melanoma cells
• coumarins
• furanocoumarins
• NMR
• Prangos pabularia
• yuganin B

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors are grateful for the National Key R&D Program of China (No. 2020YFE0205600), the Chinese Academy of Sciences President’s International Fellowship Initiative (No. 2021VBB0013), Central Asian Drug Discovery & Development Center of Chinese Academy of Sciences (Grant No. CAM 201808), CAS “Light of West China” Program 2018-YDYLTD-001 and CAS-TWAS Fellowship for Sunbula Atolikshoeva.