Chemical constituents from the seeds of Cullen corylifolium and their inhibitory activity on diacylglycerol acyltransferase

Abstract

A large number of extracts of medicinal plants or natural products shows beneficial to combat obesity. In the present work, a new flavonoid named (2S,1″R,2″R)-4′-hydroxy-7-methoxy-6-(1,2,3-trihydroxy-3-methyl-butyl)-flavanone (1), along with seven known compounds (2–8) were isolated from the seeds of Cullen corylifolium. Their structures, including the absolute configurations, were determined by the analysis of comprehensive spectroscopic data and computational calculation methods. All isolates were evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity. Compounds 1–4 exhibited different level of DGAT1 inhibitory activity with IC₅₀ values ranging from 28.2 ± 1.1 to 127.3 ± 1.9 μM. In addition, 45 flavonoids which be evaluated for DGAT inhibitory activity were summarised and potential structure–activity relationships were discussed.

Graphical Abstract

Keywords:

• Cullen corylifolium
• Fabaceae
• flavonoid
• obesity
• DGAT

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported from the National Natural Science Foundation of China (81903537), Research Foundation of Binzhou Medical University (BY2021KYQD30), and Research Start-up Foundation for Introducing High-level Talents in 2021 (2021-08).